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We have produced a large-scale computational biology analysis of the SNO-proteome in the cortex of Shank3 mutant mice (a popular model of ASD [171, 282, 283]) and found that among the NO-related molecular alterations, the most prominent change was the activation of the mTOR signaling pathway [171, 176]

Dopaminergic Agents Drugs that increase dopamine signaling, including pramipexole (Mirapex), ropinirole (Requip), and transdermal rotigotine (Neupro), as well as levodopa plus carbidopa (Sinemet), were historically recommended as first-line therapies for RLS and have well-established efficacy (Dopp 2026

In order to assess the study level risk of bias, we used the modified Cochrane risk of bias tool [22], and we evaluated the certainty of the evidence using the GRADE [20]

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As a result, it inhibited SREBP-1c expression, reduced lipid accumulation, and affected ABCA1 expression