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Mechanistically, TDC promotes apoptosis, upregulates key pro-apoptotic genes like p53 and bax, while simultaneously downregulating oncogenic genes such as bcl2, p21, and xiap

M.BrandtJ.AlbertM.et al

In a MASLD model using global Msr1 knockout mice, MSR1 deficiency protected against diet-induced metabolic dysfunction, with fewer hepatic foamy macrophages, less hepatic inflammation, improved dyslipidemia and glucose tolerance, and altered hepatic lipid metabolism (120)

[PubMed: 4137321] 7

It is anchored to the endoplasmic reticulum (ER) membrane via a hydrophobic amino acid sequence at its C-terminal end (Ayer et al., 2016)

Immune resiliency depends on nutrient availability and the health of our natural physical barriers