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Nas ltimas dcadas, pesquisadores passaram a estudar verses sintticas desses compostos, ou seja, desenvolvidas em laboratrio para reproduzir ou potencializar determinadas funes naturais do corpo

The compounds require injection, and access can be limited due to cost and shortages

Chronic morphine induces tolerance and desensitization of mu-opioid receptor but not down-regulation in rabbit

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Methodological nuances concerning probe application and detection further influence the interpretation of these findings (Clauzure et al., 2021)