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[70] Drug resistance [edit] Alteration of ARs may lead to treatment resistance (castration resistance) in prostate cancer as there may be missense mutations of the ligand binding domain, amplifications of the gene coding for this receptor or in its enhancer, mostly, suggesting the presence of different subclones with different genotypes of these receptors

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145 F-box protein FBXL2, known as a negative regulator of stemness by targeting the transcription factor E47 for polyubiquitination and proteasome-mediated degradation in breast cancer, is significantly down-regulated in paclitaxel-resistant TNBC cells