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A rational approach to this objective combines the principles of pharmacokinetics with pharmacodynamics to clarify the dose-effect relationship ( Figure 31 )

(3) the frequency of disputes and the timeliness of their resolution, which may highlight issues that we cannot directly measure, such as administrative burden

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They also described the glial reaction upon cuprizone treatment and showed that the extent of demyelination in the CC, as detected by histological staining, could be easily scored, providing investigators with a reproducible and well predictable animal model for de- and remyelination