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KA receptor is composed of GluR57 and KA1/2 subunits forming a tetrameric channel ( Figure 2 ) ( 3 Glutamate transporters/exchangers and regulation of glutamatergic signaling in the TME The maintenance of the balance between the extracellular and the intracellular glutamate is made by transporters, that are expressed by tumor and immune cells

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A combinatorial library of biodegradable lipid nanoparticles preferentially deliver mRNA into tumor cells to block mutant RAS signaling