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Tranexamic acid has been studied extensively for melasma and has shown significant improvement, especially when combined with other brighteners like niacinamide or kojic acid

Oral glutathione is never absorbed. One controlled short trial found no significant change, while longer and formulation-specific studies reported increased measurements

in Human Development: Marriage and Family Therapy from Virginia Tech

Plant Physiol 146:12821292 Lu S, Su W, Li H, Guo Z (2009) Abscisic acid improves drought tolerance of triploid bermudagrass and involves H 2 O 2 - and NO-induced antioxidant enzyme activities

THC - anandamide which calms glutamate activity Glutamate is front and center in all of these

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