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5.3 S-acylation in -cells S-acylation has been shown to be an important regulator of ion channels, vesicle trafficking, and small GTPAses, controlling many aspects of protein sorting, membrane localization, and lipid metabolism ( ATP channel activity is strongly modulated by S-acylation, which causes channel opening, counteracting the ability of ATP to close the channel ( 2+ channels ( 2+ influx and insulin exocytosis ( Figure 2 )

154, 491497 10.1083/jcb.200103047 [DOI] [PMC free article] [PubMed] [Google Scholar] Janzer R

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