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To reduce clearance and increase the serum half-life, polyethylene glycol-5000 (PEG5000) was conjugated to the molecule

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This design additionally enables prolonged circulation time and controlled release of the therapeutic agent, ultimately achieving precise delivery to tau-related Alzheimer's pathological lesions in AD mice (Zhou et al., 2020)

The overall mortality rate among adults with SE is approximately 20%, and patients who have a first episode of SE are at substantial risk for future episodes and the development of chronic epilepsy (Xu et al