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CastilloSMuozPBehrensMIDiaz-GrezFSegura-AguilarJ

S.KcS.DasA.AnjumN.PoudelA.et al

Conclusion: Are MIC and B12 Injections Worth It

In glaucoma, high IOP downregulates SLC7A11 expression, leading to reduced cystine uptake and glutamate accumulation, which doubly exacerbate ferroptosis in retinal ganglion cells (RGCs) (19)

Further studies suggested that the mechanism might involve the suppression of the TLR4/MyD88/NF-B signaling pathway by AS-IV, which downregulates the expression of downstream inflammatory cytokines such as TNF-, IL-6, and IL-8, thereby alleviating the inflammatory response induced by liver steatosis (Liu et al., 2020)