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Suppression of SPTBN2 or enhancement of HAR1A-mediated MYC degradation increases cisplatin sensitivity by inhibiting adaptive autophagy or directly triggering ferroptosis (119,120)

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Although several steps forward have been made in order to translate these results into clinical practice, currently there is a gap between preclinical research and clinical trials that need to be filled

For the hypoxic experiments, medium was incubated in the hypoxic chamber for 48 h before use for the treatment of 1919 and 2012.2 cells

Enzymatic antioxidants, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, neutralize ROS, while non-enzymatic antioxidants like vitamin C, vitamin E, and glutathione protect against cellular damage