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, Higher Mediterranean Diet Quality Scores and Lower Body Mass Index Are Associated with a Less-Oxidized Plasma Glutathione and Cysteine Redox Status in Adults, J

J.BarbalhoS

But, the researchers write, more than two dozen therapies based on the amyloid hypothesis have already been created, and none have produced meaningful clinical benefit. So why would aducanumab fare any better

Walvekar et al., 2018)

doi: 10.1021/acs.joc.1c00360

Because SOD1 knockout mice do not develop ALS per se [82], and due to the lack of correlation between SOD1 dismutase activity and aggressiveness of clinical phenotypes [83], it has been suggested that mutSOD1 exerts its deleterious effect by a toxic gain of function rather than by altered SOD1 activity [84]