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(a) the cysteine must be in the nucleophilic thiolate form [59] to donate electrons to the O-O bond in ROOH and (b) a hydrogen donor must be close enough to protonate the very poor leaving group RO to form ROH, a good leaving group

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Evidence Assessment for the Degradation Claim The scientific claim that mixing these peptides causes degradation due to pH incompatibility fails to meet evidentiary standards for several reasons: Structural incompatibility with the mechanism: The postulated copper-catalyzed oxidation pathway requires methionine or cysteine residues in the target peptides

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Just at reduced bioavailability (approximately 3540% lower than fasted-state dosing)