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Subcutaneous inflammation of contiguous nodules leads to the development of abscesses (ie cavity filled with pus presenting as a hot, red, swollen and painful lump), sinus tracks (ie tunnel or cavity leading to skin surface), fistulae (abnormal channel leading between two cavities or surfaces that drain material such as pus) and scarring (Figures 1cf)

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Ermer et al., 2011), and the subjective effects are not enhanced by parenteral administration in contrast to D-amphetamine (Lile et al., 2011) thus reducing the risk of parenteral misuse of lisdexamfetamine compared with D-amphetamine

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However, the pathological mechanism revolves around inflammatory and oxidative stress markers