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Concomitantly, co-culture with GMSCs under two conditions led to a comparable increase in the secretion of IL-10, a signature anti-inflammatory cytokine of pro-regenerative (M2) macrophages, compared with THP-1 macrophages or GMSCs cultured alone (Fig

B , Cumulative TAM consumed in milligrams (mg) by sex ( n = 2 cages/sex)

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The observed risk for metformin-induced vitamin B 12 deficiency demonstrated an additive effect for rs1801222 genotype, with both AG (OR 1.37 [95% CI 1.21, 1.54], I 2 =18.6%) and AA (OR 2.30 [95% CI 1.99, 2.65], I 2 =0%) genotype groups being at increased risk vs the GG group

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