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Scaling up

Side Effects of NAC NAC is generally well tolerated, but some people experience mild side effects, particularly at higher doses: Nausea or stomach discomfort (the most common complaint, usually resolves after a few days or by taking with food) Diarrhoea at higher doses A sulphurous smell or taste (NAC is a sulphur-containing compound) Rarely, headache or skin rash NAC can interact with certain medications, particularly nitroglycerin (used for angina), where it may enhance the blood-pressure-lowering effect

Myofibroblasts, the key effector cells in fibrosis, arise from fibroblasts, pericytes, endothelial cells, or epithelial cells via epithelialmesenchymal transition (EMT) under stimulation by transforming growth factor (TGF) -, clotting factors, and mechanical stress [11, 29, 34, 36]

Gefitinib inhibited the downregulation of ER by EGFR and restored the sensitivity of cells to tamoxifen to a certain extent (Jeong et al., 2019)

The copper component is not merely a passive constituent but actively contributes to the biological effect

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