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Patients with acute pancreatitis caused by gallstones, who are strongly suspected of harboring common bile duct stones on the basis of organ failure or other signs of severe systemic toxicity (marked leukocytosis and/or fever), require evaluation for the presence of choledocholithiasis, preferably within the first 24 h of admission

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Constipation is also common, reported in around 24% of users across clinical trial populations

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Severe gastrointestinal disease (gastroparesis, severe IBD) Tirzepatide slows gastric emptying