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Importantly, cell viability was not affected, meaning the compound did not simply kill fat cells but changed their metabolic behavior

There was a significant decrease in serum concentrations of coagulation factors including PAI-1 and the cell adhesion molecules VCAM-1 and ICAM-1, while there was an increase in IL-13 and IL-8 between T1 and T2 (Extended Data Fig

Some committee members said that they worried about the implications of the FDA allowing itself to skip over clinical trials when permitting pharmacies to dispense medications

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