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Although KRAS activation and P53 deletion are present in non-small cell lung cancer (NSCLC) and PDAC, the two tumors utilize BCAA differently despite the same initial events

FDA-approved therapeutic peptides have undergone extensive clinical trials with documented safety profiles

Under normoxic conditions, HIF-1 is rapidly degraded by PHD, but it accumulates when the PHD activity is repressed by low oxygen tension or iron chelators

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If its second derivative is positive at all points then the function is strictly convex, but the converse does not hold