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Athletes With High Training Volume Endurance training, repeated heavy resistance work, and high-volume metabolic conditioning all generate oxidative stress

It also i nteracts with multiple biologi cal pathways, providing cytoprotective, neuroprotective, and anti-inflammatory effects

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10.1038/s41467-021-27837-w 122 Van VlietE

Likewise, the origin of the glutathione that accumulates in this compartment remains unclear, as does whether external factors, such as glutathione-rich diets or direct intake of this compound as an antioxidant supplement, might influence its levels in the tumour microenvironment

Whether combinations produce additive or synergistic effects remains an open question requiring further mechanistic study