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ESC prevented hepatocyte apoptosis by reducing the Bcl-2-to-BAX ratio and inhibiting caspase-3 activation

Glutathione combats this stress by donating electrons to neutralize free radicals

Upregulation of RAGE is known mostly for playing a detrimental role associated with various pathologies

Collectively, these results demonstrate that DLBCL cells, regardless of subtype, exhibit profound sensitivity to ferroptosis induction via small molecule GPX4 inhibition, and that this vulnerability is specific to malignant B-cells, supporting ferroptosis as a selective and mechanistically distinct strategy for therapeutic intervention in aggressive lymphomas

To date, various compounds of Se have been tested to induce apoptosis involving various signaling pathways [101]

doi: 10.1038/s41467-023-36209-5 399 YehH.IkezuT