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Effects of the COOH-terminal tripeptide -MSH1113 on corneal epithelial wound healing: Role of nitric oxide

2 Materials and methods 2.1 Protein structures and evaluation The hMRP1 ( and hMRP7 ( structures were predicted using AlphaFold ( Evaluation of the AlphaFold predicted model protein structures was performed using pLDDT (predicted Local Distance Difference Test) (Sippl, 1993), ERRAT (Williams et al., 2018)) integrated within the SWISS-MODEL workspace (Waterhouse et al., 2018)

In fact, the benefits of MOTS-c on the heart were likened to those of aerobic exercise improving cardiac energy metabolism, reducing pathological remodeling, and enhancing angiogenesis (formation of new blood vessels) in cardiac tissue

Indeed mutation of Thr 365 to alanine in UGT74F1 decreased SAG activity by 75% and increased SGE activity by 300%, suggesting an important role of this residue in catalysis and substrate recognition