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Interestingly, no homologues of key papain-like proteases cathepsins B and C (dipeptidyl peptidase I), which participate in blood digestion in ticks and other blood-feeding parasites 19,20 , were identified in the D

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Upon ligand binding, this presumably membrane-bound receptor transduces intracellular chemical/redox signals that relay messages for the regulation of gene expression, a phenomenon mainly involving the activation of transcription factors [2, 13, 14, 1618, 26, 34, 51, 70]

The use of P5091 or P22077, two USP7 inhibitors, display a strong senolytic activity in several models of senescence 31