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Ablation of neutrophil-specific elastase in mice resulted in resistance to diet induced obesity, reduced IR, increased fatty acid oxidation in the liver and decreased infiltration of macrophages in adipose tissue (41, 42)

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Comorbidity severity demonstrates a doseresponse relationship

Bortey-Sam N, Nakayama SMM, Akoto O, Ikenaka Y, Fobil JN, Baidoo E, Mizukawa H, Ishizuka M (2015) Accumulation of heavy metals and metalloid in foodstuffs from agricultural soils around Tarkwa area in Ghana, and associated human health risks

The compound has also been evaluated in metabolic conditions related to HIV, including hepatic steatosis, with emerging evidence suggesting benefit in reducing intrahepatic lipid content and modulating fibrotic progression

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