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We thank Catherine Sampson for her assistance with the mouse blood collection and epididymis fat-pad isolation procedures

When looking at the endogenous NAD + fluxes at the systemic level, most organs do not synthesize NAD + de novo, but can utilize NAM made in the liver 39

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Babula JJ, Bui D, Stevenson HL, et al

They do not resemble migraines with aura or severe tension headaches

In addition, obtaining certain therapeutic radionuclides like Actinium-225 and Astatine-211 is difficult due to the limited number of facilities producing these radionuclides