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Protein Pept Lett 20(10):10981107 Acknowledgments This research was supported by grants from ANPYCT (PICT-2011 2155), CONICET (PIP 0273), and Universidad Nacional de Mar del Plata (EXA 566/12)

DSIP has garnered significant interest for its potential to modulate sleep architecture and other physiological processes, making it a valuable tool for researchers in neuroscience and endocrinology

432,438 Notably, the analgesic response to intravenous lidocaine, a sodium channel blocker, in PDPN patients correlates with increased SSC volume and enhanced functional connectivity between insular and corticolimbic circuits

The reason is that the source of these compounds is derived from living organisms through enzymatic polymerization, forming high molecular weight macromolecules