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After US irradiation, the sonosensitizer Ce6 produces extensive amounts of intracellular ROS to trigger PBSN38 activation and release the active SN38, thereby inducing tumor cell apoptosis in a temporal- and spatial-controllable manner and realizing potent antitumor activity (Scheme 1C)

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[DOI] [PubMed] [Google Scholar] 41.Jin H., Kanthasamy A., Ghosh A., Anantharam V., Kalyanaraman B., Kanthasamy A.G