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It is also expressed and released from endothelial cells (Cefis et al

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The regression coefficients are more conservative than individual study results because they control for confounding variables

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This is the primary impetus behind not only performing design assessments early during design development, but with a diligent approach, like ISDD, that masterfully exposes the weak areas of traditional diagnostic design that manifest covertly during the integration of other subsystems within the design