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The landscape of medical oncology in Europe by 2020

Overall, this review aims to provide a mechanistic and practical foundation for the development of next-generation protein-based transporters for microbiota-targeted therapies

Additionally reported is the direct induction of cancer cell ferroptosis by IFN- in an ACSL4-dependent manner when combined with arachidonic acid (AA)

Previous studies support these results

The LIP is dynamically set by transferrin/TfR1 uptake (iron import), ferritin (safe storage via H-chain ferroxidase activity), NCOA4-mediated ferritinophagy (ferritin degradation releasing Fe), heme turnover by HO-1 (which can paradoxically raise LIP if not matched by storage/export) and mitochondriallysosomal exchange routes that shuttle iron for heme/FeS biogenesis