glutathione synthesis inhibitor Nucleotide biosynthesis links metabolism to ferroptosis sensitivity Glutathione Synthetase - an overview

Inhibition of the NF-B Signaling Pathway NF-B is a master transcription factor that orchestrates the expression of numerous pro-inflammatory genes, including IL-1, TNF-, IL-6, iNOS, and COX-2

27,28 Mitochondria participate in glycolysis, fatty acid oxidation, and amino acid metabolism

When combined, the inhibition of NF-B or p38 MAPK may impact ROS/RNS production and reduce the generation of cytokines in patients with IBD, particularly when the disease is actively progressing (167)

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Mulcahy et al., 1994b

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