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In all three tested HCoVs (OC43, 229E, and SARS-CoV-2), G12(S) can repress infectious virus production despite its inefficient suppression of vRNA levels in the culture medium

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Nat Neurosci 22(3):401412

Our research indicates that myofibroblast markers, such as alpha smooth muscle actin (-SMA), are more prevalent in fibroblasts from aged mouse lungs compared to younger controls (Figure 3), highlighting the age-dependent increase in fibrosis susceptibility

It possesses the ability to sequester these molecules and subsequently release them in a regulated manner, thereby exerting control over cellular behavior ( The abnormal ECM can exert various influences on immune cells