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While our mechanistic data and mouse model results are compelling, a formal statistical causal inference or randomized controlled design would be required to definitively attribute hyperprogression to the immunotherapy regimen

10.1038/labinvest.2014.69 193 ZhangZ.JiangN.NiZ

Currently, deferiprone (DFP), a compound that alleviates symptoms related to PD pathology (Gutbier et al., 2020), is evaluated a in phase 2 randomized placebo-controlled clinical trial with AD patients (NCT03234686)