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Caregivers have been asking us about the use of folinic acid for their child with an autism spectrum disorder for quite a few months

Studies comparing localized versus systemic delivery for other biologics (botulinum toxin, platelet-rich plasma) suggest systemic routes produce more uniform results across larger treatment areas

No participant withdrew from any trial due to treatment-related adverse effects

The conversation includes informed consent that the combination is mechanistically defensible but not supported by randomized controlled trial evidence