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Such dysfunctional metabolic sequelae are cumulative outcomes of virus-induced HMRD involving about 10 divergent pathophysiological mechanisms, comprising of both virus-derived virulence factors as well as a multitude of extreme innate host responses

2 , e20 (2004)

Steady-state operation enables regulation of microbial density through removal of unbound microbes, continuous nutrient supply, maintenance of stable pH, and clearance of microbial metabolic wastes, while preserving accurate oxygen gradients