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Browning of White Adipose Tissue Third, and perhaps most fascinating, NNMT inhibition promotes browning of white adipose tissue - the conversion of white adipocytes into beige/brown adipocytes that contain numerous mitochondria and express uncoupling protein 1 (UCP1), enabling them to dissipate energy as heat through non-shivering thermogenesis

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For example, one study found that after taking 1,000 mcg of oral vitamin B12, only about 1.3% (13 mcg) is absorbed into the bloodstream

Research shows that increased NNMT is strongly associated with obesity, so targeting this enzyme could be beneficial for weight loss [2]

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If medication is not enough to control your pain, or if you have unpleasant side effects, your facial pain specialist may recommend other treatment options