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STAT3 exhibited strong signals in both differential expression and KEGG enrichment pathways (Figure 3B-D)

Furthermore, interventional studies in DSS-colitis suggest targeting ferroptosis could be therapeutic: -caryophyllene inhibition of macrophage lipid peroxidation and ferroptosis was linked to suppression of inflammation [12], and seliciclib-treated micethat displayed reduced epithelial ferroptosishad less severe DSS-induced colitis [41]