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However, recurrent and untreated episodes can be dangerous and interfere with normal development

Parshad O, Stevens MC, Preece MA, Thomas PW, Serjeant GR

Recent advancements further highlight TMAOs role in activating PERK across diverse tissues

doi: 10.1210/jc.2010-0191 53 StrangesSMarshallJRNatarajanRDonahueRPTrevisanMCombsGFet al

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Notably, compared with WT-resistant groups, monotherapy and combination elicited diametrically opposed trends in Mrp1 mRNA levels in KO-resistant groups across hepatic, blood, and splenic specimens: ART alone decreased hepatic and blood levels by 15.86-fold and 2.51-fold (versus 4.45-fold and 5.99-fold increases with combination), and increased splenic levels by 1.91-fold (versus a 2.56-fold decrease with combination) (Table 2 WT-R 1 versus KO-R 2 )