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Upon exposure to various stimuli, microglial and astrocytes may shift to a pro-inflammatory phenotype, which increases the release of cytokines, chemokines, and neurotoxic factors thus promoting immune stimulation, CNS inflammation, and if sustained, CNS dysfunctions (Murta et al., 2020)

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In this study, as amino acid precursors could be fed to improve concentrations of intracellular free l-cysteine, we resorted to overexpression of GK instead of loss-of-function mutations in GPR for accumulation of -glutamyl phosphate to strengthen the redirection of -glutamyl phosphate to GSH synthesis

Table 32 in the CY 2025 PFS proposed rule (89 FR 61862), which is the same as the following Table 35, lists the flat benchmarks for an inverse Medicare CQM under our proposal described in section IV.A.4.f.(1)(c)(i) of the CY 2025 PFS proposed rule

Neurological Health: Glutathione has been studied for its potential neuroprotective properties

and Weigel, D., "On reconciling the interactions between APETALA2, miR172 and AGAMOUS with the ABC model of flower development", Development 137 (21): 3633-3642 (2010)