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In addition to copper, an ion of Zn++ is also bound by the enzyme and likely plays a role in the catalysis

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The complement binding and inhibitory protein CbiA of Borrelia miyamotoi degrades extracellular matrix components by interacting with plasmin(ogen)

moreover, its ability to inhibit oxidative stress and inflammation can prevent heart failure with preserved ejection fraction (HFpEF) (97)

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