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(3) HA is portrayed as a significant component of skin cells, noted for its moisture-binding potential and actions on cell proliferation and inflammation, with different molecular weights (LMW and HMW) showing distinct biological activities

The biological evidence is robust at the cellular level, and clinical results are promising but limited by small study sizes, industry sponsorship, and absence of independent replication

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Still, when dealing with dogs that cannot be handled with with the help of standard medications, when facing slow-healing wounds, inflammatory diseases, and cases that could not respond well to the traditional medicines, it is still an interesting option, which needs to be carefully considered

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Minimize freeze-thaw cycles after reconstitution by following established laboratory protocols