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Despite their effectiveness, challenges persistespecially the limited central nervous system penetration of oximes, rapid aging of phosphorylated enzymes, and variability in OP compound responsiveness

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(5) Preclinical assessment: Thorough preclinical evaluation of nanomaterials in relevant animal models and in vitro assays is essential to identify and address potential safety concerns before progressing to clinical trials [341]

Skn7p, is a transcription factor which works under stress condition and also has a role in oxidative stress response in association with the Yap1p transcription factor (Lee et al., 1999)