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Megestrol acetate for treatment of anorexia-cachexia syndrome

Knockdown of either SLC7A5 or SLC7A11 led to a modest reduction in KYN uptake, suggesting cooperative involvement of multiple transporters rather than one dominant pathway (Extended Data Fig

Immunofluorescence staining of cultured neurons To determine the effect of lithium on neuronal morphology, neuron cultures were fixed with 4% paraformaldehyde for 30 min at room temperature, permeabilized with 0.25% Triton X-100 in phosphate buffer saline for 10 min, blocked with 5% donkey serum (Jackson Laboratories, PA) for 1 h at room temperature, and then incubated for 16 h at 4C with rabbit anti-microtubule-associated protein (MAP)2 antibody (Millipore, MA)

Pharmacological interventions to ameliorate neuropathological symptoms in a mouse model of Lafora Disease

Wilson and Matschinsky, 2020)

Serrano added that older populations were also at higher risk, as cases of B12 deficiency increase with age