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Furthermore, the histone lysine methyltransferase SETD1A contributes to sorafenib resistance, suggesting that targeting SETD1A could improve therapeutic outcomes in HCC [111]

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For instance, cholesterol in tumors can cause CD8 + T cell exhaustion by triggering endoplasmic reticulum stress and activating XBP1 (139)

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This work is also supported by the BLR&D/DMRS Award (1I01BX005051) to A.V.S

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