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EClinicalMedicine 57 , 101850 (2023)

Gachon and Mesquida (2020) found that collagen fibrils from adult rat tail tendons treated with glutaraldehyde do not show normal strain-stiffening and strain-softening behavior ( i.e ., excessive crosslinking causes fibrils to continue stiffening through higher strains, resulting in a more brittle behavior during fracture), differently from untreated control fibrils that exhibit strain-stiffening and strain-softening ( i.e ., fibrils initially straighten in response to strain before the fibrils themselves undergo softening at higher strains)