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Depletion of GPX4 in mice is known to induce ferroptotic cell death in embryo, testis, brain, liver, heart, and photoreceptor cells [48], cause rapid motor neuron degeneration and paralysis [49], promotes cognitive impairment [50], triggers acute renal failure [51], and results in impaired T-cell-mediated immune response [52]

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doi: 10.1016/j.ajps.2017.08.004 26

Transdermal delivery of (-)-epigallocatechin-3-gallate, a green tea polyphenol, in mice

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