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Glutathiones Role in Protecting the Liver from Damage Glutathiones protective role extends beyond its antioxidant properties

In addition, it was reported in DRG neurons of wild type mice and TRPA1 knockout mice that activation of TRPV1 by chemotherapeutic agents induced excessive ROS production and mechanical allodynia

Nat Commun 16:2412 Lido HH, Jonsson S, Hyytia P, Ericson M, Soderpalm B (2017) Further characterization of the GlyT-1 inhibitor Org25935: anti-alcohol, neurobehavioral, and gene expression effects

10.28941/pjwsr.v28i3.1058 76 HeC.WangZ.ShiJ

HMOX1 protects cell through its byproduct bilirubin, and its overexpression reduces ROS levels and lipid peroxidation

However, one of its driving factors is the reduction of pro-inflammatory cytokines, such as TNF-, and the increase in pro-inflammatory enzymes (110)