amino acid precursors to glutathione Biosynthesis pathway of (GSH) from Glutathione: Overview of its protective

To further elucidate the potential molecular mechanisms by which SAC alleviates UC, this study aims to investigate how SAC targets the Keap1/Nrf2/GPX4 signaling pathway to suppress ferroptosis in intestinal epithelial cells during UC, thereby restoring intestinal barrier integrity

Gutop et al

Marianna University School of Medicine, 9 Kitasato University School of Medicine, 10 National University Hospital, 11 Nagoya University Graduate School of Medicine, 12 Nagoya City University Graduate School of Medical Sciences, 13 University of Washington, 14 Hospital Italiano de Buenos Aires, 15 Shinmatsudo Central General Hospital, 16 Osaka Metropolitan University Graduate School of Medicine, 17 Nippon Medical School, 18 Saga University Hospital, 19 Teine Keijinkai Hospital, 20 Asahi General Hospital, 21 Kagawa Prefectural Central Hospital, 22 Kaohsiung Medical University Hospital, Kaohsiung Medical University, 23 Hanyang University, College of Medicine

[DOI] [PubMed] [Google Scholar] 164

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Glutathione is an antioxidant made up of three types of amino acids: glycine, cysteine, and glutamic acid