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Reason 2: The vial and seal can be damaged Water expands by about 9% when it freezes

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Ogawa, R., Mitsuhashi, K., Hyakusoku, H

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Many pharmacists agree that if Paracetamol was invented today, that it would be a prescription-only drug.[7] Just a few extra pills per day can make the difference between a healthy pain relief and acute liver toxicity.[8] No other drug causes more liver failure than Paracetamol