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Acyl coenzyme A synthase long chain family member 4 (ACSL4) esterifies CoA to free fatty acids, especially polyunsaturated fatty acids, and radiotherapy can collectively promote lipid peroxidation and ultimately ferroptosis by generating large amounts of ROS and upregulating the expression of the key enzyme ACSL4

Interfaces 6, 22482254 (2014)

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This mechanism has been proposed as a contributing factor to the development of fatty liver and metabolic syndrome

Mar 30 2020;10(4)doi:10.3390/ani10040581