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In addition, the GST superfamily, particularly GSTP, is known to be a protein associated with diseases 10

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In fact, before the recognition of glutamate transport activities, VGLUT1 and VGLUT2 were originally cloned as plasma membrane Na + -dependent inorganic phosphate transporters, given that their heterologous expression stimulates Na + /Pi co-transport into Xenopus oocytes (Ni et al., + -dependent phosphate transport (Juge et al., + -dependent Pi transport into SVs, which competes with glutamate transport (Preobraschenski et al., + exchange in SVs, which would convert pH to , thereby facilitating the -driven glutamate transport (Preobraschenski et al., Despite accumulating in vitro evidence from mechanistic insights into glutamate transport modulation by various ions, the physiological relevance of the foregoing biochemical observations in living synapses is largely unexplored, mainly due to technical constraints in manipulating and quantitatively measuring glutamate and various ion concentrations in the cytoplasm and in vesicle lumens

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